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1r1b

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EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE

Structural highlights

1r1b is a 1 chain structure with sequence from Cricetulus griseus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYEP_CRIGR

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these repeated motifs was also solved by NMR spectroscopy. One repeat is built around an antiparallel coiled-coil. Strikingly, the conserved lysine and arginine residues form a basic patch on one side of the structure, presenting a suitable docking surface for nucleic acids. Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor.

A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.,Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M. A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases. EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942 doi:10.1093/emboj/19.3.445

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r1b"

@@ Line 1: / Line 1: @@
 ==EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE==
-<StructureSection load='1r1b' size='340' side='right'caption='[[1r1b]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1r1b' size='340' side='right'caption='[[1r1b]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1r1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cho_cell_lines Cho cell lines]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1r1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1B FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1b OCA], [https://pdbe.org/1r1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1b RCSB], [https://www.ebi.ac.uk/pdbsum/1r1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1b ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1b OCA], [https://pdbe.org/1r1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1b RCSB], [https://www.ebi.ac.uk/pdbsum/1r1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1b ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SYEP_CRIGR SYEP_CRIGR]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Cho cell lines]]
+[[Category: Cricetulus griseus]]
 [[Category: Large Structures]]
-[[Category: Berthonneau, E]]
+[[Category: Berthonneau E]]
-[[Category: Birlirakis, N]]
+[[Category: Birlirakis N]]
-[[Category: Cahuzac, B]]
+[[Category: Cahuzac B]]
-[[Category: Guittet, E]]
+[[Category: Guittet E]]
-[[Category: Mirande, M]]
+[[Category: Mirande M]]
-[[Category: Ligase]]
-[[Category: Protein transcription]]

1r1b

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Current revision

EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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