1ucv

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Current revision (23:51, 27 December 2023) (edit) (undo)
 
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==Sterile alpha motif (SAM) domain of ephrin type-A receptor 8==
==Sterile alpha motif (SAM) domain of ephrin type-A receptor 8==
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<StructureSection load='1ucv' size='340' side='right'caption='[[1ucv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1ucv' size='340' side='right'caption='[[1ucv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ucv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UCV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ucv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UCV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA fh16961 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transferase Transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ucv OCA], [https://pdbe.org/1ucv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ucv RCSB], [https://www.ebi.ac.uk/pdbsum/1ucv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ucv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ucv TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ucv OCA], [https://pdbe.org/1ucv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ucv RCSB], [https://www.ebi.ac.uk/pdbsum/1ucv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ucv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ucv TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/EPHA8_HUMAN EPHA8_HUMAN]] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
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[https://www.uniprot.org/uniprot/EPHA8_HUMAN EPHA8_HUMAN] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Goroncy A]]
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[[Category: Goroncy, A]]
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[[Category: Inoue M]]
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[[Category: Inoue, M]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T]]
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[[Category: Kobayashi N]]
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[[Category: Kobayashi, N]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S]]
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[[Category: Tochio N]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Tochio, N]]
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[[Category: Yokoyama, S]]
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[[Category: Developmental regulation]]
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[[Category: Receptor oligomerization]]
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[[Category: Rsgi]]
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[[Category: Tyrosine kinase]]
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Current revision

Sterile alpha motif (SAM) domain of ephrin type-A receptor 8

PDB ID 1ucv

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