1pbr
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1pbr.jpg|left|200px]] | [[Image:1pbr.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1pbr", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1pbr| PDB=1pbr | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE''' | '''STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBR OCA]. | |
==Reference== | ==Reference== | ||
Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic., Fourmy D, Recht MI, Blanchard SC, Puglisi JD, Science. 1996 Nov 22;274(5291):1367-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8910275 8910275] | Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic., Fourmy D, Recht MI, Blanchard SC, Puglisi JD, Science. 1996 Nov 22;274(5291):1367-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8910275 8910275] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Blanchard, S.]] | [[Category: Blanchard, S.]] | ||
[[Category: Fourmy, D.]] | [[Category: Fourmy, D.]] | ||
[[Category: Puglisi, J D.]] | [[Category: Puglisi, J D.]] | ||
[[Category: Recht, M I.]] | [[Category: Recht, M I.]] | ||
| - | [[Category: | + | [[Category: Aminoglycoside]] |
| - | [[Category: | + | [[Category: Antibiotic]] |
| - | [[Category: | + | [[Category: Ribonucleic acid]] |
| - | [[Category: | + | [[Category: Ribosomal rna]] |
| - | [[Category: | + | [[Category: Rna transcript]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:54:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:55, 3 May 2008
STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
Aminoglycoside antibiotics that bind to 30S ribosomal A-site RNA cause misreading of the genetic code and inhibit translocation. The aminoglycoside antibiotic paromomycin binds specifically to an RNA oligonucleotide that contains the 30S subunit A site, and the solution structure of the RNA-paromomycin complex was determined by nuclear magnetic resonance spectroscopy. The antibiotic binds in the major groove of the model A-site RNA within a pocket created by an A-A base pair and a single bulged adenine. Specific interactions occur between aminoglycoside chemical groups important for antibiotic activity and conserved nucleotides in the RNA. The structure explains binding of diverse aminoglycosides to the ribosome, their specific activity against prokaryotic organisms, and various resistance mechanisms, and provides insight into ribosome function.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic., Fourmy D, Recht MI, Blanchard SC, Puglisi JD, Science. 1996 Nov 22;274(5291):1367-71. PMID:8910275 Page seeded by OCA on Sat May 3 04:54:58 2008
