1v6b

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Current revision (23:58, 27 December 2023) (edit) (undo)
 
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==Solution structure of the third PDZ domain of mouse harmonin==
==Solution structure of the third PDZ domain of mouse harmonin==
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<StructureSection load='1v6b' size='340' side='right'caption='[[1v6b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1v6b' size='340' side='right'caption='[[1v6b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1v6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V6B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1v6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V6B FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 2010016F01 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6b OCA], [https://pdbe.org/1v6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v6b RCSB], [https://www.ebi.ac.uk/pdbsum/1v6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6b ProSAT], [https://www.topsan.org/Proteins/RSGI/1v6b TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6b OCA], [https://pdbe.org/1v6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v6b RCSB], [https://www.ebi.ac.uk/pdbsum/1v6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6b ProSAT], [https://www.topsan.org/Proteins/RSGI/1v6b TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/USH1C_MOUSE USH1C_MOUSE]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:19447093</ref>
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[https://www.uniprot.org/uniprot/USH1C_MOUSE USH1C_MOUSE] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:19447093</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Nameki, N]]
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[[Category: Nameki N]]
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[[Category: Structural genomic]]
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[[Category: Saito K]]
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[[Category: Saito, K]]
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[[Category: Yamada K]]
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[[Category: Yamada, K]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Protein binding]]
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[[Category: Rsgi]]
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[[Category: Ush1]]
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[[Category: Usher syndrome]]
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Current revision

Solution structure of the third PDZ domain of mouse harmonin

PDB ID 1v6b

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