2bid

From Proteopedia

(Difference between revisions)

Current revision

HUMAN PRO-APOPTOTIC PROTEIN BID

Structural highlights

2bid is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BID_HUMAN The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains eight alpha helices where two central hydrophobic helices are surrounded by six amphipathic ones. The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although sequence homology to BCL-XL is limited to the 16-residue BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex. Additionally, we show that the overall structure of BID is preserved after cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent and -independent modes of action in inducing mitochondrial damage.

Solution structure of BID, an intracellular amplifier of apoptotic signaling.,Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G Cell. 1999 Mar 5;96(5):615-24. PMID:10089877^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD, Whyte MK. Three novel Bid proteins generated by alternative splicing of the human Bid gene. J Biol Chem. 2004 Jan 23;279(4):2846-55. Epub 2003 Oct 28. PMID:14583606 doi:http://dx.doi.org/10.1074/jbc.M309769200
↑ Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 1999 Mar 5;96(5):615-24. PMID:10089877

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bid"

@@ Line 1: / Line 1: @@
 ==HUMAN PRO-APOPTOTIC PROTEIN BID==
-<StructureSection load='2bid' size='340' side='right'caption='[[2bid]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+<StructureSection load='2bid' size='340' side='right'caption='[[2bid]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2bid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BID FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2bid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BID FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bid OCA], [https://pdbe.org/2bid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bid RCSB], [https://www.ebi.ac.uk/pdbsum/2bid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bid ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bid OCA], [https://pdbe.org/2bid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bid RCSB], [https://www.ebi.ac.uk/pdbsum/2bid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bid ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN]] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref>
+[https://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Chou, J J]]
+[[Category: Chou JJ]]
-[[Category: Li, H]]
+[[Category: Li H]]
-[[Category: Salvesen, G S]]
+[[Category: Salvesen GS]]
-[[Category: Wagner, G]]
+[[Category: Wagner G]]
-[[Category: Yuan, J]]
+[[Category: Yuan J]]
-[[Category: Apoptosis]]
-[[Category: Apoptosis regulation and amplification]]
-[[Category: Programmed cell death]]

2bid

From Proteopedia

Current revision

HUMAN PRO-APOPTOTIC PROTEIN BID

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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