2o8u

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Current revision (00:15, 28 December 2023) (edit) (undo)
 
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<StructureSection load='2o8u' size='340' side='right'caption='[[2o8u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2o8u' size='340' side='right'caption='[[2o8u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2o8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O8U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o8t|2o8t]], [[2o8w|2o8w]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8u OCA], [https://pdbe.org/2o8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8u RCSB], [https://www.ebi.ac.uk/pdbsum/2o8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8u OCA], [https://pdbe.org/2o8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o8u RCSB], [https://www.ebi.ac.uk/pdbsum/2o8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o8u ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Urokinase 3D Structures|Urokinase 3D Structures]]
*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: U-plasminogen activator]]
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[[Category: Huang M]]
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[[Category: Huang, M]]
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[[Category: Huang Z]]
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[[Category: Huang, Z]]
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[[Category: Jiang L]]
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[[Category: Jiang, L]]
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[[Category: Yuan C]]
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[[Category: Yuan, C]]
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[[Category: Zhao G]]
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[[Category: Zhao, G]]
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[[Category: Benzamidine]]
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[[Category: Contact area]]
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[[Category: Hydrolase]]
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[[Category: Phenylguanidine]]
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[[Category: Urokinase-type plasminogen activator]]
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Current revision

Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors

PDB ID 2o8u

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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