2ocw

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Current revision (00:16, 28 December 2023) (edit) (undo)
 
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<StructureSection load='2ocw' size='340' side='right'caption='[[2ocw]]' scene=''>
<StructureSection load='2ocw' size='340' side='right'caption='[[2ocw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ocw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ocw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iga|1iga]], [[1r70|1r70]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIGR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocw OCA], [https://pdbe.org/2ocw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocw RCSB], [https://www.ebi.ac.uk/pdbsum/2ocw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocw OCA], [https://pdbe.org/2ocw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocw RCSB], [https://www.ebi.ac.uk/pdbsum/2ocw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
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[https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bonner, A]]
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[[Category: Bonner A]]
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[[Category: Corthesy, B]]
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[[Category: Corthesy B]]
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[[Category: Perkins, S J]]
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[[Category: Perkins SJ]]
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[[Category: Perrier, C]]
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[[Category: Perrier C]]
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[[Category: Antibody]]
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[[Category: Immune system]]
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[[Category: Immunity]]
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[[Category: Immunoglobulin]]
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[[Category: Sc]]
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[[Category: Secretory]]
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Current revision

Solution structure of human secretory component

PDB ID 2ocw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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