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1pd2

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[[Image:1pd2.gif|left|200px]]
[[Image:1pd2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pd2 |SIZE=350|CAPTION= <scene name='initialview01'>1pd2</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1pd2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GTT:GLUTATHIONE'>GTT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1pd2| PDB=1pd2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pd2 OCA], [http://www.ebi.ac.uk/pdbsum/1pd2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pd2 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE'''
'''CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE'''
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[[Category: Ago, H.]]
[[Category: Ago, H.]]
[[Category: Miyano, M.]]
[[Category: Miyano, M.]]
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[[Category: gst]]
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[[Category: Gst]]
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[[Category: hematopoietic prostaglandin d synthase]]
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[[Category: Hematopoietic prostaglandin d synthase]]
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[[Category: pgd]]
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[[Category: Pgd]]
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[[Category: sigma-class gst]]
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[[Category: Sigma-class gst]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:57:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:58:03 2008''
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Revision as of 01:57, 3 May 2008

Image:1pd2.gif

Template:STRUCTURE 1pd2

CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE


Overview

Hematopoietic prostaglandin (PG) D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells. We isolated a cDNA for the rat enzyme, crystallized the recombinant enzyme, and determined the three-dimensional structure of the enzyme complexed with glutathione at 2.3 A resolution. The enzyme is the first member of the sigma class glutathione S-transferase (GST) from vertebrates and possesses a prominent cleft as the active site, which is never seen among other members of the GST family. The unique 3-D architecture of the cleft leads to the putative substrate binding mode and its catalytic mechanism, responsible for the specific isomerization from PGH2 to PGD2.

About this Structure

1PD2 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Cloning and crystal structure of hematopoietic prostaglandin D synthase., Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O, Cell. 1997 Sep 19;90(6):1085-95. PMID:9323136 Page seeded by OCA on Sat May 3 04:57:14 2008

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