2om5

From Proteopedia

(Difference between revisions)

Revision as of 00:20, 28 December 2023

N-Terminal Fragment of Human TAX1

Structural highlights

2om5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.07Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CNTN2_HUMAN May play a role in the initial growth and guidance of axons. May be involved in cell adhesion.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous system during embryogenesis. It consists of six immunoglobulin-like and four fibronectin III-like domains and is anchored to the membrane by glycosylphosphatidylinositol. Herein we present the crystal structure of the four N-terminal immunoglobulin-like domains of TAG-1 (TAG-1(Ig1-4)), known to be important in heterophilic and homophilic macromolecular interactions. The contacts of neighboring molecules within the crystal were investigated. A comparison with the structure of the chicken ortholog resulted in an alternative mode for the molecular mechanism of homophilic TAG-1 interaction. This mode of TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog.

The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.,Mortl M, Sonderegger P, Diederichs K, Welte W Protein Sci. 2007 Oct;16(10):2174-83. Epub 2007 Aug 31. PMID:17766378^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Mortl M, Sonderegger P, Diederichs K, Welte W. The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction. Protein Sci. 2007 Oct;16(10):2174-83. Epub 2007 Aug 31. PMID:17766378 doi:10.1110/ps.072802707

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2om5"

@@ Line 3: / Line 3: @@
 <StructureSection load='2om5' size='340' side='right'caption='[[2om5]], [[Resolution|resolution]] 3.07&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2om5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OM5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2om5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OM5 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CNTN2, TAG1, TAX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.07&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2om5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2om5 OCA], [https://pdbe.org/2om5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2om5 RCSB], [https://www.ebi.ac.uk/pdbsum/2om5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2om5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CNTN2_HUMAN CNTN2_HUMAN]] May play a role in the initial growth and guidance of axons. May be involved in cell adhesion.
+[https://www.uniprot.org/uniprot/CNTN2_HUMAN CNTN2_HUMAN] May play a role in the initial growth and guidance of axons. May be involved in cell adhesion.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Diederichs, K]]
+[[Category: Diederichs K]]
-[[Category: Moertl, M]]
+[[Category: Moertl M]]
-[[Category: Sonderegger, P]]
+[[Category: Sonderegger P]]
-[[Category: Welte, W]]
+[[Category: Welte W]]
-[[Category: Cell adhesion]]
-[[Category: Fibronectin]]
-[[Category: Ig-like c2-type]]
-[[Category: Immunoglobulin superfamily]]
-[[Category: Membrane protein]]
-[[Category: X-ray crystallography]]

2om5

From Proteopedia

Revision as of 00:20, 28 December 2023

N-Terminal Fragment of Human TAX1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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