2opv
From Proteopedia
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==Solution NMR Structure of the Second Domain of KSRP== | ==Solution NMR Structure of the Second Domain of KSRP== | ||
| - | <StructureSection load='2opv' size='340' side='right'caption='[[2opv | + | <StructureSection load='2opv' size='340' side='right'caption='[[2opv]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2opv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2opv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opv OCA], [https://pdbe.org/2opv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opv RCSB], [https://www.ebi.ac.uk/pdbsum/2opv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opv OCA], [https://pdbe.org/2opv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opv RCSB], [https://www.ebi.ac.uk/pdbsum/2opv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Diaz-Moreno | + | [[Category: Diaz-Moreno I]] |
| - | [[Category: Garcia-Mayoral | + | [[Category: Garcia-Mayoral MF]] |
| - | [[Category: Hollingworth | + | [[Category: Hollingworth D]] |
| - | [[Category: Ramos | + | [[Category: Ramos A]] |
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Current revision
Solution NMR Structure of the Second Domain of KSRP
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