3f4m

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Current revision (00:28, 28 December 2023) (edit) (undo)
 
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<StructureSection load='3f4m' size='340' side='right'caption='[[3f4m]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3f4m' size='340' side='right'caption='[[3f4m]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.696&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFAIP8L2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4m OCA], [https://pdbe.org/3f4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4m RCSB], [https://www.ebi.ac.uk/pdbsum/3f4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4m OCA], [https://pdbe.org/3f4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4m RCSB], [https://www.ebi.ac.uk/pdbsum/3f4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TP8L2_HUMAN TP8L2_HUMAN]] Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
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[https://www.uniprot.org/uniprot/TP8L2_HUMAN TP8L2_HUMAN] Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Zhang, X]]
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[[Category: Zhang X]]
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[[Category: Immune homeostasis]]
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[[Category: Immune system]]
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[[Category: Tipe2]]
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[[Category: Tnfaip8]]
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Current revision

Crystal structure of TIPE2

PDB ID 3f4m

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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