5otm

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==Crystal structure of human MTH1 in complex with O6-methyl-dGMP==
==Crystal structure of human MTH1 in complex with O6-methyl-dGMP==
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<StructureSection load='5otm' size='340' side='right' caption='[[5otm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5otm' size='340' side='right'caption='[[5otm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5otm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OTM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5otm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OTM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5otm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5otm OCA], [http://pdbe.org/5otm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5otm RCSB], [http://www.ebi.ac.uk/pdbsum/5otm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5otm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5otm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5otm OCA], [https://pdbe.org/5otm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5otm RCSB], [https://www.ebi.ac.uk/pdbsum/5otm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5otm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5otm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5otm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Berglund, U Warpman]]
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[[Category: Large Structures]]
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[[Category: Brautigam, L]]
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[[Category: Brautigam L]]
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[[Category: Gustafsson, R]]
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[[Category: Carreras Puigvert J]]
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[[Category: Helleday, T]]
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[[Category: Gustafsson R]]
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[[Category: Henriksson, L]]
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[[Category: Helleday T]]
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[[Category: Homan, E]]
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[[Category: Henriksson L]]
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[[Category: Jemth, A S]]
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[[Category: Homan E]]
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[[Category: Puigvert, J Carreras]]
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[[Category: Jemth A-S]]
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[[Category: Stenmark, P]]
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[[Category: Stenmark P]]
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[[Category: Complex]]
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[[Category: Warpman Berglund U]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Methylated nucleotide]]
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[[Category: Mth1]]
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[[Category: Nudix]]
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[[Category: O6-methyl-dgmp]]
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Current revision

Crystal structure of human MTH1 in complex with O6-methyl-dGMP

PDB ID 5otm

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