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8gcp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein== | |
| - | + | <StructureSection load='8gcp' size='340' side='right'caption='[[8gcp]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8gcp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P2E:(Z)-7-[(1R,2R,3R)-3-HYDROXY-2-[(E,3S)-3-HYDROXYOCT-1-ENYL]-5-OXO-CYCLOPENTYL]HEPT-5-ENOIC+ACID'>P2E</scene></td></tr> |
| - | [[Category: Huang | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcp OCA], [https://pdbe.org/8gcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcp RCSB], [https://www.ebi.ac.uk/pdbsum/8gcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcp ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Sheng | + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> |
| - | [[Category: Sun | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Huang SM]] | ||
| + | [[Category: Liu L]] | ||
| + | [[Category: Mu J]] | ||
| + | [[Category: Sheng C]] | ||
| + | [[Category: Sun J]] | ||
| + | [[Category: Xiong MY]] | ||
Current revision
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
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Categories: Homo sapiens | Large Structures | Huang SM | Liu L | Mu J | Sheng C | Sun J | Xiong MY
