8jxu

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'''Unreleased structure'''
 
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The entry 8jxu is ON HOLD until Paper Publication
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==Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition==
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<StructureSection load='8jxu' size='340' side='right'caption='[[8jxu]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JXU FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jxu OCA], [https://pdbe.org/8jxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jxu RCSB], [https://www.ebi.ac.uk/pdbsum/8jxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jxu ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MRP2_HUMAN MRP2_HUMAN] Dubin-Johnson syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/MRP2_HUMAN MRP2_HUMAN] ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505).<ref>PMID:10220572</ref> <ref>PMID:10421658</ref> <ref>PMID:11500505</ref> <ref>PMID:12441801</ref> <ref>PMID:16332456</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen YX]]
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[[Category: Chen ZP]]
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[[Category: Hou WT]]
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[[Category: Mao YX]]
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[[Category: Wang L]]
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[[Category: Zhou CZ]]

Revision as of 11:02, 3 January 2024

Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition

PDB ID 8jxu

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OCA

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