1pfz

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[[Image:1pfz.gif|left|200px]]
[[Image:1pfz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pfz |SIZE=350|CAPTION= <scene name='initialview01'>1pfz</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1pfz", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ASP:Catalytic+Residues+In+The+Mature+Enzyme'>ASP</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1pfz| PDB=1pfz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pfz OCA], [http://www.ebi.ac.uk/pdbsum/1pfz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pfz RCSB]</span>
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}}
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'''PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM'''
'''PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM'''
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[[Category: Loetscher, H.]]
[[Category: Loetscher, H.]]
[[Category: Ridley, R G.]]
[[Category: Ridley, R G.]]
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[[Category: aspartic proteinase zymogen]]
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[[Category: Aspartic proteinase zymogen]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hemoglobinase]]
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[[Category: Hemoglobinase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: malaria]]
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[[Category: Malaria]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:02:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:59:08 2008''
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Revision as of 02:02, 3 May 2008

Image:1pfz.gif

Template:STRUCTURE 1pfz

PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM


Overview

Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.

About this Structure

1PFZ is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum., Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN, Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289 Page seeded by OCA on Sat May 3 05:02:42 2008

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