1pgw
From Proteopedia
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'''BEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENT''' | '''BEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENT''' | ||
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[[Category: Johnson, J E.]] | [[Category: Johnson, J E.]] | ||
[[Category: Lin, T.]] | [[Category: Lin, T.]] | ||
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| - | [[Category: | + | [[Category: Icosahedral virus]] |
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Revision as of 02:04, 3 May 2008
BEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENT
Overview
Ordered nucleic acid in an icosahedral virus was first visualized in the X-ray structure of the Picorna-like plant virus, Bean pod mottle virus (BPMV). Virus particles containing the 3500 nucleotide segment of the BPMV bipartite RNA genome (middle component) had nearly 20% of the genome ordered. Here we report the refined structures of the middle component, bottom component (particles containing the 5800 nucleotide segment of the genome), and top component (empty particles of BPMV capsid protein). The bottom component particles contain ordered RNA in the same location as middle component. Although the ordered RNA density in both nucleoprotein particles is the average of the contents of 60 icosahedral asymmetric units, both nucleoprotein components show that the base density for the first two nucleotides is predominantly purine, while the next five appear to be predominantly pyrimidine. The empty capsid demonstrates that RNA dictates the order of the N-terminal 19 residues of the large subunit because these residues are invisible in the top component.
About this Structure
1PGW is a Protein complex structure of sequences from Bean pod mottle virus. Full crystallographic information is available from OCA.
Reference
Evidence for assembly-dependent folding of protein and RNA in an icosahedral virus., Lin T, Cavarelli J, Johnson JE, Virology. 2003 Sep 15;314(1):26-33. PMID:14517057 Page seeded by OCA on Sat May 3 05:04:20 2008
