8c1h

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'''Unreleased structure'''
 
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The entry 8c1h is ON HOLD until Paper Publication
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==Aurora A kinase in complex with TPX2-inhibitor 8==
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<StructureSection load='8c1h' size='340' side='right'caption='[[8c1h]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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Authors: Fischer, G., Rocaboy, M., Blaszczyk, B., Moschetti, T., Wang, X., Scott, D.E., Coyne, A.G., Dagostin, C., Rooney, T., Bayly, A., Feng, J., Asteian, A., Alcaide-Lopez, A., Stockwell, S., Skidmore, J., Venkitaraman, A.R., Abell, C., Blundell, T.L., Hyvonen, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C1H FirstGlance]. <br>
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Description: Aurora A kinase in complex with TPX2-inhibitor 8
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.233&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T3U:4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide'>T3U</scene>, <scene name='pdbligand=T5L:(1~{R},2~{R})-cyclohexane-1,2-dicarboxylic+acid'>T5L</scene></td></tr>
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[[Category: Blundell, T.L]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c1h OCA], [https://pdbe.org/8c1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c1h RCSB], [https://www.ebi.ac.uk/pdbsum/8c1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c1h ProSAT]</span></td></tr>
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[[Category: Feng, J]]
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</table>
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[[Category: Hyvonen, M]]
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== Function ==
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[[Category: Scott, D.E]]
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[https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>
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[[Category: Alcaide-Lopez, A]]
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== References ==
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[[Category: Fischer, G]]
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<references/>
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[[Category: Abell, C]]
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__TOC__
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[[Category: Stockwell, S]]
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</StructureSection>
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[[Category: Asteian, A]]
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[[Category: Homo sapiens]]
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[[Category: Venkitaraman, A.R]]
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[[Category: Large Structures]]
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[[Category: Rooney, T]]
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[[Category: Abell C]]
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[[Category: Dagostin, C]]
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[[Category: Alcaide-Lopez A]]
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[[Category: Bayly, A]]
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[[Category: Asteian A]]
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[[Category: Skidmore, J]]
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[[Category: Bayly A]]
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[[Category: Rocaboy, M]]
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[[Category: Blaszczyk B]]
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[[Category: Blaszczyk, B]]
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[[Category: Blundell TL]]
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[[Category: Wang, X]]
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[[Category: Coyne AG]]
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[[Category: Coyne, A.G]]
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[[Category: Dagostin C]]
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[[Category: Moschetti, T]]
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[[Category: Feng J]]
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[[Category: Fischer G]]
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[[Category: Hyvonen M]]
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[[Category: Moschetti T]]
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[[Category: Rocaboy M]]
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[[Category: Rooney T]]
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[[Category: Scott DE]]
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[[Category: Skidmore J]]
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[[Category: Stockwell S]]
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[[Category: Venkitaraman AR]]
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[[Category: Wang X]]

Revision as of 10:20, 10 January 2024

Aurora A kinase in complex with TPX2-inhibitor 8

PDB ID 8c1h

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