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8tbw

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'''Unreleased structure'''
 
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The entry 8tbw is ON HOLD until Paper Publication
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==Human Class I MHC HLA-A2 in complex with sorting nexin 24 (127-135) peptide KLSHQPVLL==
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<StructureSection load='8tbw' size='340' side='right'caption='[[8tbw]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8tbw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TBW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.081&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tbw OCA], [https://pdbe.org/8tbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tbw RCSB], [https://www.ebi.ac.uk/pdbsum/8tbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tbw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q53Z42_HUMAN Q53Z42_HUMAN] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Major histocompatibility complex (MHC) proteins present peptides on the cell surface for T cell surveillance. Reliable in silico prediction of which peptides would be presented and which T cell receptors would recognize them is an important problem in structural immunology. Here, we introduce an AlphaFold-based pipeline for predicting the three-dimensional structures of peptide-MHC complexes for class I and class II MHC molecules. Our method demonstrates high accuracy, outperforming existing tools in class I modeling accuracy and class II peptide register prediction. We validate its performance and utility with new experimental data on a recently described cancer neoantigen/wild-type peptide pair and explore applications toward improving peptide-MHC binding prediction.
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Authors: Arbuiso, A., Weiss, L.I., Brambley, C.A., Ma, J., Keller, G.L.J., Ayres, C.M., Baker, B.M.
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Accurate modeling of peptide-MHC structures with AlphaFold.,Mikhaylov V, Brambley CA, Keller GLJ, Arbuiso AG, Weiss LI, Baker BM, Levine AJ Structure. 2023 Dec 14:S0969-2126(23)00413-6. doi: 10.1016/j.str.2023.11.011. PMID:38113889<ref>PMID:38113889</ref>
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Description: Human Class I MHC HLA-A2 in complex with sorting nexin 24 (127-135) peptide KLSHQPVLL
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Weiss, L.I]]
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<div class="pdbe-citations 8tbw" style="background-color:#fffaf0;"></div>
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[[Category: Keller, G.L.J]]
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== References ==
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[[Category: Baker, B.M]]
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<references/>
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[[Category: Brambley, C.A]]
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__TOC__
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[[Category: Ayres, C.M]]
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</StructureSection>
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[[Category: Arbuiso, A]]
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[[Category: Homo sapiens]]
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[[Category: Ma, J]]
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[[Category: Large Structures]]
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[[Category: Arbuiso A]]
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[[Category: Ayres CM]]
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[[Category: Baker BM]]
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[[Category: Brambley CA]]
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[[Category: Keller GLJ]]
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[[Category: Ma J]]
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[[Category: Weiss LI]]

Revision as of 10:27, 10 January 2024

Human Class I MHC HLA-A2 in complex with sorting nexin 24 (127-135) peptide KLSHQPVLL

PDB ID 8tbw

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