1r54

From Proteopedia

Revision as of 16:53, 12 November 2007

Crystal structure of the catalytic domain of human ADAM33

Overview

Adam33 is a putative asthma susceptibility gene encoding for a, membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs, (a disintegrin and metalloprotease) are a family of glycoproteins, implicated in cell-cell interactions, cell fusion, and cell signaling. We, have determined the crystal structure of the Adam33 catalytic domain in, complex with the inhibitor marimastat and the inhibitor-free form. The, structures reveal the polypeptide fold and active site environment, resembling that of other metalloproteases. The substrate-binding site, contains unique features that allow the structure-based design of specific, inhibitors of this enzyme.

About this Structure

1R54 is a Single protein structure of sequence from Homo sapiens with ZN, CA and CL as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745

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