1r55

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Revision as of 16:53, 12 November 2007

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spinqualitylabelsall models 1r55, resolution 1.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of the catalytic domain of human ADAM 33

Overview

Adam33 is a putative asthma susceptibility gene encoding for a, membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs, (a disintegrin and metalloprotease) are a family of glycoproteins, implicated in cell-cell interactions, cell fusion, and cell signaling. We, have determined the crystal structure of the Adam33 catalytic domain in, complex with the inhibitor marimastat and the inhibitor-free form. The, structures reveal the polypeptide fold and active site environment, resembling that of other metalloproteases. The substrate-binding site, contains unique features that allow the structure-based design of specific, inhibitors of this enzyme.

About this Structure

1R55 is a Single protein structure of sequence from Homo sapiens with ZN, CA, CL and 097 as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745

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