8dhu

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'''Unreleased structure'''
 
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The entry 8dhu is ON HOLD until Paper Publication
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==Crystal structure of LARP-DM15 from Drosophila melanogaster bound to m7GpppC==
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<StructureSection load='8dhu' size='340' side='right'caption='[[8dhu]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8dhu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DHU FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.295&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=91P:[[(2~{R},3~{S},4~{R},5~{R})-5-(2-AZANYL-7-METHYL-6-OXIDANYLIDENE-1~{H}-PURIN-9-IUM-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[[(2~{R},3~{S},4~{R},5~{R})-5-(4-AZANYL-2-OXIDANYLIDENE-PYRIMIDIN-1-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+HYDROGEN+PHOSPHATE'>91P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dhu OCA], [https://pdbe.org/8dhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dhu RCSB], [https://www.ebi.ac.uk/pdbsum/8dhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dhu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LARP_DROME LARP_DROME] RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:17951964, PubMed:19631203, PubMed:30772175, PubMed:35413237). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:35413237).<ref>PMID:17951964</ref> <ref>PMID:19631203</ref> <ref>PMID:30772175</ref> <ref>PMID:35413237</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Drosophila melanogaster]]
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[[Category: Large Structures]]
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[[Category: Berman AJ]]
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[[Category: Nguyen E]]

Revision as of 10:03, 17 January 2024

Crystal structure of LARP-DM15 from Drosophila melanogaster bound to m7GpppC

PDB ID 8dhu

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