1raz

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Revision as of 16:55, 12 November 2007

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spinqualitylabelsall models 1raz, resolution 1.9Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The three-dimensional structure of human carbonic anhydrase II complexed, with azide and with bromide was investigated crystallographically. Both of, these non-protonated inhibitors replace the zinc and the 'deep' water, two, catalytically important water molecules in the active site of the, molecule. Both the azide and the bromide ions bind in a distorted, tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with, the zinc ion.

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

1RAZ is a Single protein structure of sequence from Homo sapiens with ZN and BR as ligands. Active as Carbonate dehydratase, with EC number 4.2.1.1 Full crystallographic information is available from OCA.

Reference

The structure of human carbonic anhydrase II in complex with bromide and azide., Jonsson BM, Hakansson K, Liljas A, FEBS Lett. 1993 May 10;322(2):186-90. PMID:8482389

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