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2xcn

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Current revision (12:45, 17 January 2024) (edit) (undo)
 
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<StructureSection load='2xcn' size='340' side='right'caption='[[2xcn]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
<StructureSection load='2xcn' size='340' side='right'caption='[[2xcn]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xcn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xcn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8D:N-[(CYCLOPENTYLOXY)CARBONYL]-3-METHYL-L-VALYL-(4R)-N-{(1R)-3-HYDROXY-1-[HYDROXY(OXIDO)BORANYL]PROPYL}-4-(ISOQUINOLIN-1-YLOXY)-L-PROLINAMIDE'>C8D</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xcf|2xcf]], [[2a4q|2a4q]], [[2f9u|2f9u]], [[2a4r|2a4r]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8D:N-[(CYCLOPENTYLOXY)CARBONYL]-3-METHYL-L-VALYL-(4R)-N-{(1R)-3-HYDROXY-1-[HYDROXY(OXIDO)BORANYL]PROPYL}-4-(ISOQUINOLIN-1-YLOXY)-L-PROLINAMIDE'>C8D</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcn OCA], [https://pdbe.org/2xcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xcn RCSB], [https://www.ebi.ac.uk/pdbsum/2xcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcn OCA], [https://pdbe.org/2xcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xcn RCSB], [https://www.ebi.ac.uk/pdbsum/2xcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcn ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q91RS4_9HEPC Q91RS4_9HEPC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepacivirus C]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baker, S J]]
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[[Category: Baker SJ]]
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[[Category: Ding, C Z]]
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[[Category: Ding CZ]]
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[[Category: Edge, C M]]
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[[Category: Edge CM]]
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[[Category: Ellis, M]]
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[[Category: Ellis M]]
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[[Category: Fan, D]]
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[[Category: Fan D]]
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[[Category: Grimes, R M]]
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[[Category: Grimes RM]]
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[[Category: Hubbard, J A]]
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[[Category: Hubbard JA]]
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[[Category: Jarvest, R L]]
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[[Category: Jarvest RL]]
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[[Category: Kazmierski, W M]]
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[[Category: Kazmierski WM]]
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[[Category: Lazarides, L X]]
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[[Category: Lazarides LX]]
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[[Category: Li, Q]]
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[[Category: Li Q]]
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[[Category: Li, X]]
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[[Category: Li X]]
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[[Category: Liao, L]]
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[[Category: Liao L]]
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[[Category: Liu, Y]]
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[[Category: Liu Y]]
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[[Category: McDowell, B]]
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[[Category: McDowell B]]
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[[Category: Mordaunt, J E]]
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[[Category: Mordaunt JE]]
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[[Category: Nassau, P]]
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[[Category: Nassau P]]
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[[Category: Ni, Z J]]
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[[Category: Ni Z-J]]
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[[Category: Pennicott, L E]]
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[[Category: Pennicott LE]]
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[[Category: Plattner, J J]]
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[[Category: Plattner JJ]]
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[[Category: Qian, X]]
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[[Category: Qian X]]
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[[Category: Rowland, P]]
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[[Category: Rowland P]]
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[[Category: Skarzynski, T J]]
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[[Category: Skarzynski TJ]]
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[[Category: Slater, M J]]
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[[Category: Slater MJ]]
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[[Category: Smith, G K]]
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[[Category: Smith GK]]
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[[Category: Somers, D O]]
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[[Category: Somers DO]]
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[[Category: Thommes, P]]
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[[Category: Thommes P]]
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[[Category: White, G V]]
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[[Category: White GV]]
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[[Category: Wright, J]]
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[[Category: Wright J]]
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[[Category: Wright, L L]]
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[[Category: Wright LL]]
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[[Category: Zhang, Y K]]
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[[Category: Zhang Y-K]]
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[[Category: Zhou, Y]]
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[[Category: Zhou Y]]
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[[Category: Zou, W]]
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[[Category: Zou W]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]
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Current revision

Crystal structure of HCV NS3 protease with a boronate inhibitor

PDB ID 2xcn

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Proteopedia Page Contributors and Editors (what is this?)

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