2xfm

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Current revision (12:45, 17 January 2024) (edit) (undo)
 
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==Complex structure of the MIWI Paz domain bound to methylated single stranded RNA==
==Complex structure of the MIWI Paz domain bound to methylated single stranded RNA==
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<StructureSection load='2xfm' size='340' side='right'caption='[[2xfm]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2xfm' size='340' side='right'caption='[[2xfm]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xfm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xfm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFM FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfm OCA], [https://pdbe.org/2xfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfm RCSB], [https://www.ebi.ac.uk/pdbsum/2xfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfm OCA], [https://pdbe.org/2xfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfm RCSB], [https://www.ebi.ac.uk/pdbsum/2xfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PIWL1_MOUSE PIWL1_MOUSE]] Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability.<ref>PMID:11578866</ref>
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[https://www.uniprot.org/uniprot/PIWL1_MOUSE PIWL1_MOUSE] Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability.<ref>PMID:11578866</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Andrade-Navarro, M A]]
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[[Category: Synthetic construct]]
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[[Category: Carlomagno, T]]
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[[Category: Andrade-Navarro MA]]
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[[Category: Eckhardt, S]]
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[[Category: Carlomagno T]]
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[[Category: Kirkpatrick, J P]]
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[[Category: Eckhardt S]]
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[[Category: Pillai, R S]]
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[[Category: Kirkpatrick JP]]
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[[Category: Sehr, P]]
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[[Category: Pillai RS]]
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[[Category: Simon, B]]
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[[Category: Sehr P]]
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[[Category: Differentiation]]
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[[Category: Simon B]]
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[[Category: Rna interference]]
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[[Category: Rna-protein complex]]
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Current revision

Complex structure of the MIWI Paz domain bound to methylated single stranded RNA

PDB ID 2xfm

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