1pma

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1pma.gif|left|200px]]
[[Image:1pma.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1pma |SIZE=350|CAPTION= <scene name='initialview01'>1pma</scene>, resolution 3.4&Aring;
+
The line below this paragraph, containing "STRUCTURE_1pma", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1pma| PDB=1pma | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pma OCA], [http://www.ebi.ac.uk/pdbsum/1pma PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pma RCSB]</span>
+
-
}}
+
'''PROTEASOME FROM THERMOPLASMA ACIDOPHILUM'''
'''PROTEASOME FROM THERMOPLASMA ACIDOPHILUM'''
Line 32: Line 29:
[[Category: Stock, D.]]
[[Category: Stock, D.]]
[[Category: Zwickl, P.]]
[[Category: Zwickl, P.]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
[[Category: proteasome]]
+
[[Category: Proteasome]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:14:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:35 2008''
+

Revision as of 02:14, 3 May 2008

Image:1pma.gif

Template:STRUCTURE 1pma

PROTEASOME FROM THERMOPLASMA ACIDOPHILUM


Overview

The three-dimensional structure of the proteasome from the archaebacterium Thermoplasma acidophilum has been elucidated by x-ray crystallographic analysis by means of isomorphous replacement and cyclic averaging. The atomic model was built and refined to a crystallographic R factor of 22.1 percent. The 673-kilodalton protease complex consists of 14 copies of two different subunits, alpha and beta, forming a barrel-shaped structure of four stacked rings. The two inner rings consist of seven beta subunits each, and the two outer rings consist of seven alpha subunits each. A narrow channel controls access to the three inner compartments. The alpha 7 beta 7 beta 7 alpha 7 subunit assembly has 72-point group symmetry. The structures of the alpha and beta subunits are similar, consisting of a core of two antiparallel beta sheets that is flanked by alpha helices on both sides. The binding of a peptide aldehyde inhibitor marks the active site in the central cavity at the amino termini of the beta subunits and suggests a novel proteolytic mechanism.

About this Structure

1PMA is a Protein complex structure of sequences from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution., Lowe J, Stock D, Jap B, Zwickl P, Baumeister W, Huber R, Science. 1995 Apr 28;268(5210):533-9. PMID:7725097 Page seeded by OCA on Sat May 3 05:14:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pma"
Personal tools