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1pma

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[[Image:1pma.gif|left|200px]]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pma OCA], [http://www.ebi.ac.uk/pdbsum/1pma PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pma RCSB]</span>
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'''PROTEASOME FROM THERMOPLASMA ACIDOPHILUM'''
'''PROTEASOME FROM THERMOPLASMA ACIDOPHILUM'''
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[[Category: Stock, D.]]
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[[Category: Zwickl, P.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: proteasome]]
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[[Category: Proteasome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:14:40 2008''
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Revision as of 02:14, 3 May 2008

Image:1pma.gif

Template:STRUCTURE 1pma

PROTEASOME FROM THERMOPLASMA ACIDOPHILUM


Overview

The three-dimensional structure of the proteasome from the archaebacterium Thermoplasma acidophilum has been elucidated by x-ray crystallographic analysis by means of isomorphous replacement and cyclic averaging. The atomic model was built and refined to a crystallographic R factor of 22.1 percent. The 673-kilodalton protease complex consists of 14 copies of two different subunits, alpha and beta, forming a barrel-shaped structure of four stacked rings. The two inner rings consist of seven beta subunits each, and the two outer rings consist of seven alpha subunits each. A narrow channel controls access to the three inner compartments. The alpha 7 beta 7 beta 7 alpha 7 subunit assembly has 72-point group symmetry. The structures of the alpha and beta subunits are similar, consisting of a core of two antiparallel beta sheets that is flanked by alpha helices on both sides. The binding of a peptide aldehyde inhibitor marks the active site in the central cavity at the amino termini of the beta subunits and suggests a novel proteolytic mechanism.

About this Structure

1PMA is a Protein complex structure of sequences from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution., Lowe J, Stock D, Jap B, Zwickl P, Baumeister W, Huber R, Science. 1995 Apr 28;268(5210):533-9. PMID:7725097 Page seeded by OCA on Sat May 3 05:14:40 2008

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