7gsh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOPL000530a== | |
| - | + | <StructureSection load='7gsh' size='340' side='right'caption='[[7gsh]], [[Resolution|resolution]] 1.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7gsh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7GSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7GSH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=WLY:2-(4-methylphenyl)-N-{[(2S)-oxolan-2-yl]methyl}acetamide'>WLY</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7gsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7gsh OCA], [https://pdbe.org/7gsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7gsh RCSB], [https://www.ebi.ac.uk/pdbsum/7gsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7gsh ProSAT]</span></td></tr> |
| - | [[Category: Ginn | + | </table> |
| - | [[Category: Keedy | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ginn HM]] | ||
| + | [[Category: Keedy DA]] | ||
| + | [[Category: Mehlman T]] | ||
Current revision
PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOPL000530a
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