8fw3

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'''Unreleased structure'''
 
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The entry 8fw3 is ON HOLD until Paper Publication
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==MtrR from Neisseria gonorrhoeae bound to Testosterone==
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<StructureSection load='8fw3' size='340' side='right'caption='[[8fw3]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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Authors: Hooks, G.H., Brennan, R.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FW3 FirstGlance]. <br>
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Description: MtrR from Neisseria gonorrhoeae bound to Testosterone
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene></td></tr>
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[[Category: Brennan, R.G]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fw3 OCA], [https://pdbe.org/8fw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fw3 RCSB], [https://www.ebi.ac.uk/pdbsum/8fw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fw3 ProSAT]</span></td></tr>
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[[Category: Hooks, G.H]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTRR_NEIGO MTRR_NEIGO] Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents (PubMed:8196548). Represses transcription of the mtrCDE-encoded efflux pump by binding within the mtrCDE promoter (PubMed:9209024, PubMed:23221802). Also negatively regulates the expression of farR, by binding to its promoter region, leading indirectly to the positive regulation of expression of the farAB-encoded efflux pump (PubMed:14645274).<ref>PMID:14645274</ref> <ref>PMID:23221802</ref> <ref>PMID:8196548</ref> <ref>PMID:9209024</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Neisseria gonorrhoeae]]
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[[Category: Brennan RG]]
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[[Category: Hooks GH]]

Revision as of 11:25, 24 January 2024

MtrR from Neisseria gonorrhoeae bound to Testosterone

PDB ID 8fw3

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