8gdy

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m (Protected "8gdy" [edit=sysop:move=sysop])
Current revision (11:25, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8gdy is ON HOLD until Paper Publication
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==Crystal structure of the human PDI first domain with 9 mutations==
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<StructureSection load='8gdy' size='340' side='right'caption='[[8gdy]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors: Forouhar, F., Banayan, N.E., Loughlin, B.L., Singh, S., Wong, V., Hunt, H.S., Handelman, S.K., Price, N., Hunt, J.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gdy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GDY FirstGlance]. <br>
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Description: Crystal structure of the human PDI first domain with 9 mutations
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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[[Category: Handelman, S.K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gdy OCA], [https://pdbe.org/8gdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gdy RCSB], [https://www.ebi.ac.uk/pdbsum/8gdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gdy ProSAT]</span></td></tr>
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[[Category: Forouhar, F]]
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</table>
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[[Category: Wong, V]]
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== Function ==
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[[Category: Price, N]]
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[https://www.uniprot.org/uniprot/PDIA1_HUMAN PDIA1_HUMAN] This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.<ref>PMID:10636893</ref> <ref>PMID:12485997</ref>
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[[Category: Hunt, H.S]]
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== References ==
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[[Category: Banayan, N.E]]
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<references/>
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[[Category: Loughlin, B.L]]
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__TOC__
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[[Category: Hunt, J.F]]
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</StructureSection>
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[[Category: Singh, S]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Banayan NE]]
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[[Category: Forouhar F]]
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[[Category: Handelman SK]]
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[[Category: Hunt HS]]
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[[Category: Hunt JF]]
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[[Category: Loughlin BL]]
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[[Category: Price N]]
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[[Category: Singh S]]
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[[Category: Wong V]]

Current revision

Crystal structure of the human PDI first domain with 9 mutations

PDB ID 8gdy

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