1pmi

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[[Image:1pmi.gif|left|200px]]
[[Image:1pmi.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pmi |SIZE=350|CAPTION= <scene name='initialview01'>1pmi</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1pmi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1pmi| PDB=1pmi | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pmi OCA], [http://www.ebi.ac.uk/pdbsum/1pmi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pmi RCSB]</span>
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}}
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'''HUMAN RANTES'''
'''HUMAN RANTES'''
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[[Category: Wells, T N.C.]]
[[Category: Wells, T N.C.]]
[[Category: Wonacott, A.]]
[[Category: Wonacott, A.]]
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[[Category: aldose-ketose isomerase]]
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[[Category: Aldose-ketose isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:15:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:39 2008''
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Revision as of 02:15, 3 May 2008

Image:1pmi.gif

Template:STRUCTURE 1pmi

HUMAN RANTES


Overview

Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.

About this Structure

1PMI is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:8612079 Page seeded by OCA on Sat May 3 05:15:03 2008

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OCA

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