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6hm3

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Current revision (11:32, 24 January 2024) (edit) (undo)
 
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==Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide==
==Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide==
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<StructureSection load='6hm3' size='340' side='right' caption='[[6hm3]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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<StructureSection load='6hm3' size='340' side='right'caption='[[6hm3]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hm3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HM3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hm3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HM3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7726362&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hm3 OCA], [http://pdbe.org/6hm3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hm3 RCSB], [http://www.ebi.ac.uk/pdbsum/6hm3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hm3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hm3 OCA], [https://pdbe.org/6hm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hm3 RCSB], [https://www.ebi.ac.uk/pdbsum/6hm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hm3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAD4_SCHPO RAD4_SCHPO]] Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. [[http://www.uniprot.org/uniprot/SLD3_SCHPO SLD3_SCHPO]] Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Plays a role in meiosis.<ref>PMID:12006645</ref> <ref>PMID:16303567</ref>
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[https://www.uniprot.org/uniprot/RAD4_SCHPO RAD4_SCHPO] Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hm3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hm3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA repair protein Rad4|DNA repair protein Rad4]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Day, M]]
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[[Category: Large Structures]]
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[[Category: Oliver, A W]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Pearl, L H]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Rappas, M]]
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[[Category: Day M]]
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[[Category: Brct domain phosphopeptide recognition]]
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[[Category: Oliver AW]]
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[[Category: Cell cycle]]
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[[Category: Pearl LH]]
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[[Category: Rappas M]]

Current revision

Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide

PDB ID 6hm3

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