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6hn2

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Current revision (11:33, 24 January 2024) (edit) (undo)
 
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==Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5==
==Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5==
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<StructureSection load='6hn2' size='340' side='right' caption='[[6hn2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='6hn2' size='340' side='right'caption='[[6hn2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HN2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HN2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GF8:2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide'>GF8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GF8:2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide'>GF8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn2 OCA], [https://pdbe.org/6hn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6hn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn2 OCA], [http://pdbe.org/6hn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hn2 RCSB], [http://www.ebi.ac.uk/pdbsum/6hn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hn2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hn2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arkin, M R]]
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[[Category: Large Structures]]
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[[Category: Hallenbeck, K K]]
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[[Category: Arkin MR]]
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[[Category: Leysen, S]]
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[[Category: Hallenbeck KK]]
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[[Category: Ottmann, C]]
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[[Category: Leysen S]]
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[[Category: Sijbesma, E]]
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[[Category: Ottmann C]]
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[[Category: Fragment]]
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[[Category: Sijbesma E]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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[[Category: Stabilizer]]
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[[Category: Tethering]]
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Current revision

Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5

PDB ID 6hn2

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