6hrh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:37, 24 January 2024) (edit) (undo)
 
Line 1: Line 1:
==Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2==
==Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2==
-
<StructureSection load='6hrh' size='340' side='right' caption='[[6hrh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='6hrh' size='340' side='right'caption='[[6hrh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6hrh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HRH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6hrh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HRH FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hrh OCA], [http://pdbe.org/6hrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hrh RCSB], [http://www.ebi.ac.uk/pdbsum/6hrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hrh ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hrh OCA], [https://pdbe.org/6hrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hrh RCSB], [https://www.ebi.ac.uk/pdbsum/6hrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hrh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>
+
[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: 5-aminolevulinate synthase]]
+
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Large Structures]]
-
[[Category: Bailey, H J]]
+
[[Category: Arrowsmith C]]
-
[[Category: Bountra, C]]
+
[[Category: Bailey HJ]]
-
[[Category: Burgess-Brown, N]]
+
[[Category: Bountra C]]
-
[[Category: Delft, F von]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Diaz-saez, L]]
+
[[Category: Diaz-saez L]]
-
[[Category: Edwards, A]]
+
[[Category: Edwards A]]
-
[[Category: Kennedy, E]]
+
[[Category: Kennedy E]]
-
[[Category: Kupinska, K]]
+
[[Category: Kupinska K]]
-
[[Category: Newman, J]]
+
[[Category: Newman J]]
-
[[Category: Rembeza, E]]
+
[[Category: Rembeza E]]
-
[[Category: Structural genomic]]
+
[[Category: Shrestha L]]
-
[[Category: Shrestha, L]]
+
[[Category: Yue WW]]
-
[[Category: Yue, W W]]
+
[[Category: Von Delft F]]
-
[[Category: Erythroid-specific]]
+
-
[[Category: Mitochondrial]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Sgc]]
+

Current revision

Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2

PDB ID 6hrh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6hrh"
Personal tools