6i3h
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of influenza A virus M1 N-terminal domain (G18A mutation)== | |
| + | <StructureSection load='6i3h' size='340' side='right'caption='[[6i3h]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6i3h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I3H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i3h OCA], [https://pdbe.org/6i3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i3h RCSB], [https://www.ebi.ac.uk/pdbsum/6i3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i3h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/M1_I33A0 M1_I33A0] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Influenza A virus is a pathogen of great medical impact. To develop novel antiviral strategies, it is essential to understand the molecular aspects of virus-host cell interactions in detail. During entry, the viral ribonucleoproteins (vRNPs) that carry the RNA genome must be released from the incoming particle before they can enter the nucleus for replication. The uncoating process is facilitated by histone deacetylase 6 (ref.(1)). However, the precise mechanism of shell opening and vRNP debundling is unknown. Here, we show that transportin 1, a member of the importin-beta family proteins, binds to a PY-NLS(2) sequence motif close to the amino terminus of matrix protein (M1) exposed during acid priming of the viral core. It promotes the removal of M1 and induces disassembly of vRNP bundles. Next, the vRNPs interact with importin-alpha/beta and enter the nucleus. Thus, influenza A virus uses dual importin-betas for distinct steps in host cell entry. | ||
| - | + | Influenza virus uses transportin 1 for vRNP debundling during cell entry.,Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y Nat Microbiol. 2019 Apr;4(4):578-586. doi: 10.1038/s41564-018-0332-2. Epub 2019 , Jan 28. PMID:30692667<ref>PMID:30692667</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6i3h" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Influenza A virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Decamps L]] | ||
| + | [[Category: Gut H]] | ||
| + | [[Category: Helenius A]] | ||
| + | [[Category: Ho-Xuan H]] | ||
| + | [[Category: Iketani S]] | ||
| + | [[Category: Keusch JJ]] | ||
| + | [[Category: Kutay U]] | ||
| + | [[Category: Miyake Y]] | ||
| + | [[Category: Yamauchi Y]] | ||
Current revision
Crystal structure of influenza A virus M1 N-terminal domain (G18A mutation)
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Categories: Influenza A virus | Large Structures | Decamps L | Gut H | Helenius A | Ho-Xuan H | Iketani S | Keusch JJ | Kutay U | Miyake Y | Yamauchi Y
