6i5i

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Current revision (11:47, 24 January 2024) (edit) (undo)
 
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==Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h==
==Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h==
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<StructureSection load='6i5i' size='340' side='right' caption='[[6i5i]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='6i5i' size='340' side='right'caption='[[6i5i]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6i5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I5I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6i5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I5I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H3E:5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine'>H3E</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H3E:5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine'>H3E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5i OCA], [http://pdbe.org/6i5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i5i RCSB], [http://www.ebi.ac.uk/pdbsum/6i5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5i OCA], [https://pdbe.org/6i5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i5i RCSB], [https://www.ebi.ac.uk/pdbsum/6i5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
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[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6i5i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6i5i" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Chaikuad, A]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Chaikuad A]]
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[[Category: Knapp, S]]
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[[Category: Edwards AM]]
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[[Category: Paruch, K]]
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[[Category: Knapp S]]
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[[Category: Structural genomic]]
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[[Category: Paruch K]]
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[[Category: Clk]]
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[[Category: Furopyridine]]
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[[Category: Inhibitor]]
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[[Category: Sgc]]
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[[Category: Splicing kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h

PDB ID 6i5i

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