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6iab

From Proteopedia

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Tail fiber of Staphylococcus aureus phage P68

Structural highlights

6iab is a 1 chain structure with sequence from Staphylococcus phage P68. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q859I6_9CAUD

Publication Abstract from PubMed

Phages infecting Staphylococcus aureus can be used as therapeutics against antibiotic-resistant bacterial infections. However, there is limited information about the mechanism of genome delivery of phages that infect Gram-positive bacteria. Here, we present the structures of native S. aureus phage P68, genome ejection intermediate, and empty particle. The P68 head contains 72 subunits of inner core protein, 15 of which bind to and alter the structure of adjacent major capsid proteins and thus specify attachment sites for head fibers. Unlike in the previously studied phages, the head fibers of P68 enable its virion to position itself at the cell surface for genome delivery. The unique interaction of one end of P68 DNA with one of the 12 portal protein subunits is disrupted before the genome ejection. The inner core proteins are released together with the DNA and enable the translocation of phage genome across the bacterial membrane into the cytoplasm.

Structure and genome ejection mechanism of Staphylococcus aureus phage P68.,Hrebik D, Stverakova D, Skubnik K, Fuzik T, Pantucek R, Plevka P Sci Adv. 2019 Oct 16;5(10):eaaw7414. doi: 10.1126/sciadv.aaw7414. eCollection, 2019 Oct. PMID:31663016^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hrebik D, Stverakova D, Skubnik K, Fuzik T, Pantucek R, Plevka P. Structure and genome ejection mechanism of Staphylococcus aureus phage P68. Sci Adv. 2019 Oct 16;5(10):eaaw7414. doi: 10.1126/sciadv.aaw7414. eCollection, 2019 Oct. PMID:31663016 doi:http://dx.doi.org/10.1126/sciadv.aaw7414

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6iab"

Categories: Large Structures | Staphylococcus phage P68 | Hrebik D | Karel S | Plevka P

@@ Line 3: / Line 3: @@
 <StructureSection load='6iab' size='340' side='right'caption='[[6iab]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6iab]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IAB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6iab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_phage_P68 Staphylococcus phage P68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IAB FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iab OCA], [http://pdbe.org/6iab PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iab RCSB], [http://www.ebi.ac.uk/pdbsum/6iab PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iab ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iab OCA], [https://pdbe.org/6iab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iab RCSB], [https://www.ebi.ac.uk/pdbsum/6iab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iab ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q859I6_9CAUD Q859I6_9CAUD]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Hrebik, D]]
+[[Category: Staphylococcus phage P68]]
-[[Category: Karel, S]]
+[[Category: Hrebik D]]
-[[Category: Plevka, P]]
+[[Category: Karel S]]
-[[Category: Beta-propeller]]
+[[Category: Plevka P]]
-[[Category: Receptor binding protein]]
-[[Category: Structural protein]]
-[[Category: Sugar binding protein]]

6iab

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Current revision

Tail fiber of Staphylococcus aureus phage P68

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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