6iaz
From Proteopedia
(Difference between revisions)
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==The archaeal Methanocaldococcus infernus Elp3 with N-terminus deletion (1-46)== | ==The archaeal Methanocaldococcus infernus Elp3 with N-terminus deletion (1-46)== | ||
| - | <StructureSection load='6iaz' size='340' side='right' caption='[[6iaz]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='6iaz' size='340' side='right'caption='[[6iaz]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6iaz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAZ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6iaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_infernus Methanocaldococcus infernus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IAZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iaz OCA], [https://pdbe.org/6iaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iaz RCSB], [https://www.ebi.ac.uk/pdbsum/6iaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iaz ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ELP3_METIM ELP3_METIM] tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:25151136, PubMed:30733442). The proposed mechanism is the following: (i) recruits S-adenosyl-L-methionine and cleaves it to generate a 5'-deoxyadenosine radical (5'-dA) in the radical S-adenosyl-L-methionine (rSAM) region, (ii) hydrolyzes acetyl-CoA in the N-acetyltransferase domain and (iii) an acetyl radical is formed by the products of the two domains and (iv) is transferred onto the C5 position of uridine(34) in the bound tRNA molecule (PubMed:25151136). Does not show protein lysine acetyltransferase activity (PubMed:30733442).<ref>PMID:25151136</ref> <ref>PMID:30733442</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6iaz" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6iaz" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Methanocaldococcus infernus]] |
| - | [[Category: | + | [[Category: Glatt S]] |
| - | [[Category: | + | [[Category: Lin TY]] |
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Current revision
The archaeal Methanocaldococcus infernus Elp3 with N-terminus deletion (1-46)
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