6q3w

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m (Protected "6q3w" [edit=sysop:move=sysop])
Current revision (11:52, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6q3w is ON HOLD
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==Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate==
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<StructureSection load='6q3w' size='340' side='right'caption='[[6q3w]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6q3w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q3W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.962&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HFK:2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1-cyclohexane]-5-one'>HFK</scene>, <scene name='pdbligand=HGE:ethyl+1-pyrazin-2-ylpiperidine-4-carboxylate'>HGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q3w OCA], [https://pdbe.org/6q3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q3w RCSB], [https://www.ebi.ac.uk/pdbsum/6q3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q3w ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[https://omim.org/entry/230200 230200]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Major enzyme for galactose metabolism.
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Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
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==See Also==
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*[[Galactokinase|Galactokinase]]
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Description: Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Foster, W]]
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__TOC__
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[[Category: Zhang, M]]
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</StructureSection>
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[[Category: Brandao-Neto, J]]
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[[Category: Homo sapiens]]
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[[Category: Lai, K]]
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[[Category: Large Structures]]
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[[Category: Bezerra, G.A]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A]]
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[[Category: Bezerra GA]]
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[[Category: Douangamath, A]]
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[[Category: Bountra C]]
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[[Category: Mackinnon, S.R]]
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[[Category: Brandao-Neto J]]
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[[Category: Krojer, T]]
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[[Category: Brennan P]]
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[[Category: Yue, W.W]]
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[[Category: Douangamath A]]
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[[Category: Brennan, P]]
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[[Category: Edwards A]]
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[[Category: Bountra, C]]
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[[Category: Foster W]]
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[[Category: Arrowsmith, C]]
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[[Category: Krojer T]]
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[[Category: Lai K]]
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[[Category: Mackinnon SR]]
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[[Category: Yue WW]]
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[[Category: Zhang M]]

Current revision

Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate

PDB ID 6q3w

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