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| | <StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution|resolution]] 3.60Å' scene=''> | | <StructureSection load='6qp9' size='340' side='right'caption='[[6qp9]], [[Resolution|resolution]] 3.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QP9 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6qp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QP9 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sema1a, Dsema-I, Sema-1a, CG18405 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [http://pdbe.org/6qp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qp9 OCA], [https://pdbe.org/6qp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qp9 RCSB], [https://www.ebi.ac.uk/pdbsum/6qp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qp9 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME]] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref> | + | [https://www.uniprot.org/uniprot/SEM1A_DROME SEM1A_DROME] Involved in growth cone guidance through its role in axonal repulsion.<ref>PMID:15282266</ref> <ref>PMID:8269517</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 6qp9" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6qp9" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Semaphorin 3D structures|Semaphorin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Drome]] | + | [[Category: Drosophila melanogaster]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Harlos, K]] | + | [[Category: Harlos K]] |
| - | [[Category: Jones, E Y]] | + | [[Category: Jones EY]] |
| - | [[Category: Robinson, R A]] | + | [[Category: Robinson RA]] |
| - | [[Category: Rozbesky, D]] | + | [[Category: Rozbesky D]] |
| - | [[Category: Siebold, C]] | + | [[Category: Siebold C]] |
| - | [[Category: Axon guidance cue]]
| + | |
| - | [[Category: Cell signalling]]
| + | |
| - | [[Category: Developmental protein]]
| + | |
| - | [[Category: Semaphorin]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Signalling protein]]
| + | |
| Structural highlights
Function
SEM1A_DROME Involved in growth cone guidance through its role in axonal repulsion.[1] [2]
Publication Abstract from PubMed
Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of semaphorin homodimer to plexin brings two plexins in close proximity which is a prerequisite for plexin signalling. This model appears to be too simplistic to explain the complexity and functional versatility of these molecules. Here, we determine crystal structures for all members of Drosophila class 1 and 2 semaphorins. Unlike previously reported semaphorin structures, Sema1a, Sema2a and Sema2b show stabilisation of sema domain dimer formation via a disulfide bond. Unexpectedly, our structural and biophysical data show Sema1b is a monomer suggesting that semaphorin function may not be restricted to dimers. We demonstrate that semaphorins can form heterodimers with members of the same semaphorin class. This heterodimerization provides a potential mechanism for cross-talk between different plexins and co-receptors to allow fine-tuning of cell signalling.
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.,Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y. PMID:31417095[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Ayoob JC, Yu HH, Terman JR, Kolodkin AL. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. J Neurosci. 2004 Jul 28;24(30):6639-49. doi: 10.1523/JNEUROSCI.1104-04.2004. PMID:15282266 doi:http://dx.doi.org/10.1523/JNEUROSCI.1104-04.2004
- ↑ Kolodkin AL, Matthes DJ, Goodman CS. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell. 1993 Dec 31;75(7):1389-99. PMID:8269517
- ↑ Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY. Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning. Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y. PMID:31417095 doi:http://dx.doi.org/10.1038/s41467-019-11683-y
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