6qu4

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Current revision (12:08, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6qu4' size='340' side='right'caption='[[6qu4]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='6qu4' size='340' side='right'caption='[[6qu4]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6qu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QU4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6qu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QU4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JJ2:1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino)ethyl]pyrrolo[3,2-c]pyridin-4-one'>JJ2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pfk ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JJ2:1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino)ethyl]pyrrolo[3,2-c]pyridin-4-one'>JJ2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qu4 OCA], [https://pdbe.org/6qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/6qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qu4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qu4 OCA], [https://pdbe.org/6qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/6qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qu4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
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[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-phosphofructokinase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trybb]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Dornan, J]]
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[[Category: Dornan J]]
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[[Category: McNae, I W]]
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[[Category: McNae IW]]
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[[Category: Walkinshaw, M D]]
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[[Category: Walkinshaw MD]]
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[[Category: Allostery]]
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[[Category: Glycolysis]]
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[[Category: Inhibitor]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb405

PDB ID 6qu4

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OCA

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