1poq
From Proteopedia
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'''Solution Structure of a Superantigen from Yersinia pseudotuberculosis''' | '''Solution Structure of a Superantigen from Yersinia pseudotuberculosis''' | ||
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[[Category: Liew, C W.]] | [[Category: Liew, C W.]] | ||
[[Category: Mackay, J P.]] | [[Category: Mackay, J P.]] | ||
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Revision as of 02:18, 3 May 2008
Solution Structure of a Superantigen from Yersinia pseudotuberculosis
Overview
Superantigens are a class of microbial proteins with the ability to excessively activate T cells by binding to the T cell receptor. The staphylococcal and streptococcal superantigens are closely related in structure and possess an N-terminal domain that resembles an OB fold and a C-terminal domain similar to a beta-grasp fold. Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other proteins. We have determined the crystal and solution structures of YPMa, which show that the protein has a jelly-roll fold. The closest structural neighbors to YPMa are viral capsid proteins and members of the tumor necrosis factor superfamily. In the crystal structure, YPMa packs as a trimer, another feature shared with viral capsid proteins and TNF superfamily proteins. However, in solution YPMa behaves as a monomer, and any functional relevance of the trimer observed in the crystals is yet to be established.
About this Structure
1POQ is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.
Reference
Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold., Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA, Structure. 2004 Jan;12(1):145-56. PMID:14725774 Page seeded by OCA on Sat May 3 05:18:55 2008
