|
|
| Line 3: |
Line 3: |
| | <StructureSection load='6rjk' size='340' side='right'caption='[[6rjk]], [[Resolution|resolution]] 1.92Å' scene=''> | | <StructureSection load='6rjk' size='340' side='right'caption='[[6rjk]], [[Resolution|resolution]] 1.92Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6rjk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens_a6 Agrobacterium tumefaciens a6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6rjk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens_A6 Agrobacterium tumefaciens A6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RJK FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sghA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1453998 Agrobacterium tumefaciens A6])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.922Å</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjk OCA], [https://pdbe.org/6rjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rjk RCSB], [https://www.ebi.ac.uk/pdbsum/6rjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjk ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjk OCA], [http://pdbe.org/6rjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rjk RCSB], [http://www.ebi.ac.uk/pdbsum/6rjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjk ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A0A2I4PGZ0_RHIRD A0A2I4PGZ0_RHIRD] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 17: |
Line 18: |
| | </div> | | </div> |
| | <div class="pdbe-citations 6rjk" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6rjk" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Agrobacterium tumefaciens a6]] | + | [[Category: Agrobacterium tumefaciens A6]] |
| - | [[Category: Beta-glucosidase]]
| + | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Chang, C Q]] | + | [[Category: Chang CQ]] |
| - | [[Category: Gao, Y G]] | + | [[Category: Gao YG]] |
| - | [[Category: Wang, C]] | + | [[Category: Wang C]] |
| - | [[Category: Ye, F Z]] | + | [[Category: Ye FZ]] |
| - | [[Category: Zhang, L H]] | + | [[Category: Zhang LH]] |
| - | [[Category: Agrobacterium]]
| + | |
| - | [[Category: Chemical signaling]]
| + | |
| - | [[Category: Glucosidase]]
| + | |
| - | [[Category: Host-pathogen interaction]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Sucrose]]
| + | |
| Structural highlights
Function
A0A2I4PGZ0_RHIRD
Publication Abstract from PubMed
It is highly intriguing how bacterial pathogens can quickly shut down energy-costly infection machinery once successful infection is established. This study depicts that mutation of repressor SghR increases the expression of hydrolase SghA in Agrobacterium tumefaciens, which releases plant defense signal salicylic acid (SA) from its storage form SA beta-glucoside (SAG). Addition of SA substantially reduces gene expression of bacterial virulence. Bacterial vir genes and sghA are differentially transcribed at early and later infection stages, respectively. Plant metabolite sucrose is a signal ligand that inactivates SghR and consequently induces sghA expression. Disruption of sghA leads to increased vir expression in planta and enhances tumor formation whereas mutation of sghR decreases vir expression and tumor formation. These results depict a remarkable mechanism by which A. tumefaciens taps on the reserved pool of plant signal SA to reprogram its virulence upon establishment of infection.
Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.,Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH Proc Natl Acad Sci U S A. 2019 Oct 11. pii: 1903695116. doi:, 10.1073/pnas.1903695116. PMID:31604827[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH. Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc Natl Acad Sci U S A. 2019 Oct 11. pii: 1903695116. doi:, 10.1073/pnas.1903695116. PMID:31604827 doi:http://dx.doi.org/10.1073/pnas.1903695116
|
