6rum

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Current revision (12:28, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6rum' size='340' side='right'caption='[[6rum]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='6rum' size='340' side='right'caption='[[6rum]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RUM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RUM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rul|6rul]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Camelus glama])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rum OCA], [https://pdbe.org/6rum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rum RCSB], [https://www.ebi.ac.uk/pdbsum/6rum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rum ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rum OCA], [http://pdbe.org/6rum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rum RCSB], [http://www.ebi.ac.uk/pdbsum/6rum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rum ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Camelus glama]]
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[[Category: Escherichia coli K-12]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ellenberg, J]]
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[[Category: Ellenberg J]]
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[[Category: Farrants, H]]
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[[Category: Farrants H]]
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[[Category: Hiblot, J]]
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[[Category: Hiblot J]]
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[[Category: Johnsson, K]]
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[[Category: Johnsson K]]
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[[Category: Koch, B]]
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[[Category: Koch B]]
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[[Category: Kraeusslich, H G]]
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[[Category: Kraeusslich H-G]]
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[[Category: Kueblbeck, M]]
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[[Category: Kueblbeck M]]
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[[Category: Mueller, T G]]
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[[Category: Mueller TG]]
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[[Category: Otsuka, S]]
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[[Category: Otsuka S]]
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[[Category: Tarnawski, M]]
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[[Category: Tarnawski M]]
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[[Category: Circular permutant of dhfr]]
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[[Category: Lama]]
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[[Category: Nadph]]
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[[Category: Nanobody]]
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[[Category: Protein binding]]
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[[Category: Tmp]]
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Current revision

Crystal structure of GFP-LAMA-G97 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH

PDB ID 6rum

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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