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6rwd

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Current revision (12:29, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6rwd' size='340' side='right'caption='[[6rwd]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='6rwd' size='340' side='right'caption='[[6rwd]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rwd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RWD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rwd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RWD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=REF:2,3,7,8-TETRAHYDROXYCHROMENO[5,4,3-CDE]CHROMENE-5,10-DIONE'>REF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ua5|1ua5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=REF:2,3,7,8-TETRAHYDROXYCHROMENO[5,4,3-CDE]CHROMENE-5,10-DIONE'>REF</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwd OCA], [https://pdbe.org/6rwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rwd RCSB], [https://www.ebi.ac.uk/pdbsum/6rwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwd OCA], [http://pdbe.org/6rwd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwd RCSB], [http://www.ebi.ac.uk/pdbsum/6rwd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
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[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Blood fluke]]
 
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[[Category: Glutathione transferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Achilonu, I A]]
 
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[[Category: Dirr, H W]]
 
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[[Category: Olfsen, J]]
 
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[[Category: Pandian, R]]
 
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[[Category: Sayed, Y]]
 
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[[Category: Ellagic acid]]
 
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[[Category: Gsh]]
 
[[Category: Schistosoma japonicum]]
[[Category: Schistosoma japonicum]]
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[[Category: Sjgst]]
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[[Category: Achilonu IA]]
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[[Category: Transferase]]
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[[Category: Dirr HW]]
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[[Category: Olfsen J]]
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[[Category: Pandian R]]
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[[Category: Sayed Y]]

Current revision

Crystal structure of SjGST in complex with GSH and ellagic acid at 1.53 Angstrom resolution

PDB ID 6rwd

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