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1pp5

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[[Image:1pp5.gif|left|200px]]
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{{Structure
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|GENE= MCJA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pp5 OCA], [http://www.ebi.ac.uk/pdbsum/1pp5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pp5 RCSB]</span>
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'''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''
'''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Swapna, G V.T.]]
[[Category: Swapna, G V.T.]]
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[[Category: backbone-sidechain amide linkage]]
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[[Category: Backbone-sidechain amide linkage]]
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[[Category: lariat]]
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[[Category: Lariat]]
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[[Category: nesg]]
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[[Category: Nesg]]
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[[Category: northeast structural genomics consortium]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: protoknot]]
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[[Category: Protoknot]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:19:38 2008''
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Revision as of 02:19, 3 May 2008

Image:1pp5.gif

Template:STRUCTURE 1pp5

Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot


Overview

The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within, and obstructing, the nucleotide-uptake channel of bacterial RNA polymerase. Published covalent and three-dimensional structures indicate that MccJ25 is a 21-residue cycle. Here, we show that the published covalent and three-dimensional structures are incorrect, and that MccJ25 in fact is a 21-residue "lariat protoknot", consisting of an 8-residue cyclic segment followed by a 13-residue linear segment that loops back and threads through the cyclic segment. MccJ25 is the first example of a lariat protoknot involving a backbone-side chain amide linkage.

About this Structure

1PP5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot., Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH, J Am Chem Soc. 2003 Oct 15;125(41):12382-3. PMID:14531661 Page seeded by OCA on Sat May 3 05:19:38 2008

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