6rz7

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<StructureSection load='6rz7' size='340' side='right'caption='[[6rz7]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
<StructureSection load='6rz7' size='340' side='right'caption='[[6rz7]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZ7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KNW:(2~{S})-8-[[4-[4-(2-chloranyl-5-fluoranyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-+dihydro-1,4-benzoxazine-2-carboxylic+acid'>KNW</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYSLTR2, CYSLT2, CYSLT2R, PSEC0146 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KNW:(2~{S})-8-[[4-[4-(2-chloranyl-5-fluoranyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-+dihydro-1,4-benzoxazine-2-carboxylic+acid'>KNW</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz7 OCA], [https://pdbe.org/6rz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz7 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz7 OCA], [https://pdbe.org/6rz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz7 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Uveal melanoma.
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[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN] Uveal melanoma.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN]] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Besserer-Offroy, E]]
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[[Category: Besserer-Offroy E]]
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[[Category: Borshchevskiy, V]]
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[[Category: Borshchevskiy V]]
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[[Category: Brouillette, R L]]
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[[Category: Brouillette RL]]
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[[Category: Cherezov, V]]
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[[Category: Cherezov V]]
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[[Category: Ergasheva, M]]
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[[Category: Ergasheva M]]
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[[Category: Fujimoto, T]]
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[[Category: Fujimoto T]]
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[[Category: Gordeliy, V]]
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[[Category: Gordeliy V]]
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[[Category: Gusach, A]]
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[[Category: Gusach A]]
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[[Category: Han, G W]]
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[[Category: Han GW]]
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[[Category: Ishchenko, A]]
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[[Category: Ishchenko A]]
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[[Category: Katritch, V]]
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[[Category: Katritch V]]
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[[Category: Kovalev, K]]
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[[Category: Kovalev K]]
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[[Category: Longpre, J M]]
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[[Category: Longpre JM]]
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[[Category: Luginina, A]]
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[[Category: Luginina A]]
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[[Category: Marin, E]]
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[[Category: Marin E]]
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[[Category: Maruyama, T]]
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[[Category: Maruyama T]]
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[[Category: Mishin, A]]
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[[Category: Mishin A]]
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[[Category: Popov, P]]
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[[Category: Popov P]]
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[[Category: Romanovskaya, D]]
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[[Category: Romanovskaya D]]
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[[Category: Sarret, P]]
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[[Category: Sarret P]]
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[[Category: Shevtsov, M]]
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[[Category: Shevtsov M]]
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[[Category: Stauch, B]]
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[[Category: Stauch B]]
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[[Category: Stepko, A]]
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[[Category: Stepko A]]
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[[Category: Asthma]]
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[[Category: Bril]]
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[[Category: Cyslt2]]
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[[Category: Cyslt2r]]
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[[Category: Cysltr2]]
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[[Category: Cysteinyl leukotriene]]
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[[Category: Cysteinyl leukotriene receptor 2]]
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[[Category: Gpcr]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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Revision as of 12:31, 24 January 2024

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (F222 space group)

PDB ID 6rz7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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