1pp7

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[[Image:1pp7.gif|left|200px]]
[[Image:1pp7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pp7 |SIZE=350|CAPTION= <scene name='initialview01'>1pp7</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1pp7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Trichomonas vaginalis:IBP39 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5722 Trichomonas vaginalis])
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-->
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|DOMAIN=
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{{STRUCTURE_1pp7| PDB=1pp7 | SCENE= }}
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|RELATEDENTRY=[[1pp8|1pp8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pp7 OCA], [http://www.ebi.ac.uk/pdbsum/1pp7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pp7 RCSB]</span>
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}}
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'''Crystal structure of the T. vaginalis Initiator binding protein bound to the ferredoxin Inr'''
'''Crystal structure of the T. vaginalis Initiator binding protein bound to the ferredoxin Inr'''
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[[Category: Lau, A O.T.]]
[[Category: Lau, A O.T.]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher, M A.]]
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[[Category: core promoter]]
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[[Category: Core promoter]]
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[[Category: ibp39]]
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[[Category: Ibp39]]
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[[Category: initiator]]
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[[Category: Initiator]]
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[[Category: t. vaginali]]
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[[Category: T. vaginali]]
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[[Category: transcription initation]]
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[[Category: Transcription initation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:19:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:02:39 2008''
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Revision as of 02:19, 3 May 2008

Image:1pp7.gif

Template:STRUCTURE 1pp7

Crystal structure of the T. vaginalis Initiator binding protein bound to the ferredoxin Inr


Overview

Transcription start site selection in eukaryotes is mediated through combinations of the TATA, initiator (Inr), and downstream promoter elements (DPE). In Trichomonas vaginalis, a parabasalian flagellate thought to represent an ancient eukaryote lineage, the Inr appears to be solely responsible for start site selection and is recognized by the initiator binding protein 39 kDa (IBP39). IBP39 contains an N-terminal Inr binding domain (IBD) connected via a flexible linker to a C-terminal domain (C domain). Here we present crystal structures of the apoIBD and IBD-Inr complexes and the C domain. The IBD structures reveal a winged-helix motif with prokaryotic and eukaryotic features and a scaffold similar to that of ETS-family proteins. The C domain structure and biochemical studies indicate that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. These data suggest that binding of IBP39 to the Inr directly recruits RNAP II and in this way initiates transcription.

About this Structure

1PP7 is a Single protein structure of sequence from Trichomonas vaginalis. Full crystallographic information is available from OCA.

Reference

Structural basis of core promoter recognition in a primitive eukaryote., Schumacher MA, Lau AO, Johnson PJ, Cell. 2003 Nov 14;115(4):413-24. PMID:14622596 Page seeded by OCA on Sat May 3 05:19:45 2008

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