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6s7z

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Current revision (12:36, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6s7z' size='340' side='right'caption='[[6s7z]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='6s7z' size='340' side='right'caption='[[6s7z]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6s7z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S7Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6s7z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S7Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KZN:~{N}-[5-(3,4-dihydro-1~{H}-isoquinolin-2-ylsulfonyl)-2-methoxy-phenyl]-2-(4-oxidanylidene-3~{H}-phthalazin-1-yl)ethanamide'>KZN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6s7u|6s7u]], [[6s7w|6s7w]], [[6s7k|6s7k]], [[6s43|6s43]], [[6s7s|6s7s]], [[6s88|6s88]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=KZN:~{N}-[5-(3,4-dihydro-1~{H}-isoquinolin-2-ylsulfonyl)-2-methoxy-phenyl]-2-(4-oxidanylidene-3~{H}-phthalazin-1-yl)ethanamide'>KZN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fum, fumC, DSI35_09545, ERS007663_02818, ERS007679_02635, ERS007688_02307, ERS007722_03256, ERS023446_00966, ERS024276_01230, ERS027646_00759, ERS027653_00188, ERS027654_00515, ERS027659_00384, ERS027661_00671, ERS027666_02275, ERS124361_03161, SAMEA2682864_03539, SAMEA2683035_02636 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7z OCA], [https://pdbe.org/6s7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s7z RCSB], [https://www.ebi.ac.uk/pdbsum/6s7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7z ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7z OCA], [http://pdbe.org/6s7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s7z RCSB], [http://www.ebi.ac.uk/pdbsum/6s7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A045IXZ8_MYCTX A0A045IXZ8_MYCTX]] Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.[HAMAP-Rule:MF_00743]
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[https://www.uniprot.org/uniprot/FUMC_MYCTU FUMC_MYCTU] Catalyzes the reversible addition of water to fumarate to give L-malate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6s7z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6s7z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Fumarase|Fumarase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fumarate hydratase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abell, C]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Barry, C E]]
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[[Category: Abell C]]
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[[Category: Boshoff, H I]]
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[[Category: Barry CE]]
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[[Category: Brear, P]]
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[[Category: Boshoff HI]]
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[[Category: Coyne, A G]]
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[[Category: Brear P]]
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[[Category: Fischer, G]]
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[[Category: Coyne AG]]
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[[Category: Kasbekar, M]]
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[[Category: Fischer G]]
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[[Category: Libardo, M D]]
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[[Category: Kasbekar M]]
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[[Category: Thomas, C J]]
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[[Category: Libardo MD]]
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[[Category: Whitehouse, A J]]
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[[Category: Thomas CJ]]
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[[Category: Fumarase]]
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[[Category: Whitehouse AJ]]
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[[Category: Lyase]]
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Current revision

Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide

PDB ID 6s7z

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