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6sbr

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Current revision (12:39, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6sbr' size='340' side='right'caption='[[6sbr]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
<StructureSection load='6sbr' size='340' side='right'caption='[[6sbr]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6sbr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SBR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6sbr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SBR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L5E:[(7~{S})-1,4-bis(bromanyl)-6,6-bis(oxidanyl)-5,7,8,9-tetrahydrobenzo[7]annulen-7-yl]azanium'>L5E</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L5E:[(7~{S})-1,4-bis(bromanyl)-6,6-bis(oxidanyl)-5,7,8,9-tetrahydrobenzo[7]annulen-7-yl]azanium'>L5E</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbr OCA], [http://pdbe.org/6sbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sbr RCSB], [http://www.ebi.ac.uk/pdbsum/6sbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sbr OCA], [https://pdbe.org/6sbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sbr RCSB], [https://www.ebi.ac.uk/pdbsum/6sbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sbr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6sbr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6sbr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Membrane alanyl aminopeptidase]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Alavi, S]]
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[[Category: Alavi S]]
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[[Category: Albrecht, S]]
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[[Category: Albrecht S]]
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[[Category: Cavarelli, J]]
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[[Category: Cavarelli J]]
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[[Category: Florent, I]]
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[[Category: Florent I]]
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[[Category: McEwen, A G]]
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[[Category: McEwen AG]]
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[[Category: Mouray, E]]
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[[Category: Mouray E]]
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[[Category: Poussin-Courmontagne, P]]
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[[Category: Poussin-Courmontagne P]]
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[[Category: Salomon, E]]
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[[Category: Salomon E]]
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[[Category: Schmitt, M]]
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[[Category: Schmitt M]]
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[[Category: Tarnus, C]]
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[[Category: Tarnus C]]
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[[Category: Torchy, M]]
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[[Category: Torchy M]]
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[[Category: Hydrolase]]
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[[Category: M1 aminopeptidase]]
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Current revision

The crystal structure of PfA-M1 in complex with 7-amino-1,4-dibromo-5,7,8,9-tetrahydrobenzocyclohepten-6-one

PDB ID 6sbr

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