6slz

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==Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist==
==Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist==
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<StructureSection load='6slz' size='340' side='right'caption='[[6slz]]' scene=''>
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<StructureSection load='6slz' size='340' side='right'caption='[[6slz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SLZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6slz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SLZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6slz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slz OCA], [http://pdbe.org/6slz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6slz RCSB], [http://www.ebi.ac.uk/pdbsum/6slz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6slz ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LK8:(2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide'>LK8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6slz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slz OCA], [https://pdbe.org/6slz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6slz RCSB], [https://www.ebi.ac.uk/pdbsum/6slz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6slz ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amaudrut J]]
[[Category: Amaudrut J]]

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Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist

PDB ID 6slz

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