6swt

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Current revision (12:49, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6swt' size='340' side='right'caption='[[6swt]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='6swt' size='340' side='right'caption='[[6swt]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6swt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SWT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6swt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SWT FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACTN2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swt OCA], [https://pdbe.org/6swt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swt RCSB], [https://www.ebi.ac.uk/pdbsum/6swt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swt OCA], [https://pdbe.org/6swt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swt RCSB], [https://www.ebi.ac.uk/pdbsum/6swt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swt ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[https://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
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[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[https://omim.org/entry/612158 612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
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[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6swt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6swt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Actinin 3D structures|Actinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Synthetic construct sequences]]
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[[Category: Synthetic construct]]
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[[Category: Peckham, M]]
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[[Category: Peckham M]]
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[[Category: Rogers, B]]
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[[Category: Rogers B]]
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[[Category: Trinh, C H]]
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[[Category: Trinh CH]]
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[[Category: Affimer]]
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[[Category: Alpha-actinin 2]]
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[[Category: Contractile protein]]
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Current revision

Affimer9 co-crystalised with the CH domains of alpha actinin 2.

PDB ID 6swt

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